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October 22, 2017 by u3PH.rma

Research & Development.

We are developing targeted therapies based on our understanding of disease biology. We specialize in protein therapeutics and select the drug format which may best attack the mechanisms that fuel disease progression.

As a company having its roots in the pioneering work of Axel Ullrich on cellular signaling, we have developed several antibodies which block the aberrant signal transduction in cancer cells. Interfering with these signals is a proven strategy to combat tumor development since cancer is a disease of uncontrolled growth signals.

As drivers of biomedical progress, we know exactly what is required to successfully bridge this ‘Valley of Death’ towards market entry. Many years of experience and scientific excellence are indispensable for this purpose. And, in addition, there is the immense potential that comes from partnering with one of the world’s largest pharmaceutical groups as a backdrop.

Only when it comes on the market, an active ingredient does have an impact.

The discovery of a new drug candidate is like an inner moment of realisation. A unique, emotional moment. We understand this feeling because we have experienced it ourselves on several occasions.

Only: How do you arrange for a drug candidate to receive clinical development and then be released onto the market? How can it help people and bring real value?

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October 22, 2017 by u3PH.rma

Product Pipeline

U3 Pharma is committed to developing innovative products designed to safely and effectively treat patients with cancer and improve patient outcomes.

We are focusing our resources on developing four biopharmaceutical products that are the result of the application of our translational medicine and drug discovery expertise to drug targets identified and validated by U3 Pharma´s founder Prof. Axel Ullrich.

Product	Description	Product Type	Status
U3-1287	Receptor tyrosine kinase	Human antibody	Preclinical
U3-1565	Receptor tyrosine kinase ligand	Human antibody	Preclinical
U3-1900	Ion channel	Humanized antibody	Preclinical
U3-1800	Receptor tyrosine kinase	Humanized antibody	Preclinical
U3-1784	Receptor tyrosine kinase	Antibody	Research
U3-2000	Intracellular kinase		Research
U3-1299	Intracellular kinase		Research

U3 Pharma AG – Leading programs

U3-1287
The target of U3-1287 is a membrane-bound receptor tyrosine kinase (RTK) that controls a specific signal transduction pathway and has shown involvement in multiple cancer types of epithelial origin, including breast, lung and colorectal cancers, among others. Partnered with Abgenix, now Amgen, U3 Pharma is advancing fully human therapeutic antibodies against this target. U3-1287 is anticipated to enter clinical evaluation in 2007.

U3-1565
The target of U3-1565 is a membrane-bound receptor tyrosine kinase ligand (RTKL), which is a key component of a molecular pathway, discovered and elucidated by Prof. Ullrich, involved in autocrine growth stimulation. U3 Pharma has demonstrated a pivotal role for U3-1565 in multiple cancer types of epithelial origin and has developed fully human therapeutic antibodies against the target under the company´s collaboration with Abgenix, now Amgen. The lead antibodies for this program are anticipated to enter the clinic in 2007.

U3-1900
The target of U3-1900 is an ion channel with oncogenic activity. Discovered in The Max Planck Institute by Prof. Walter Stühmer and Dr. Luis Pardo, the U3-1900 target displays a unique expression pattern identifying it as a tumor marker and target of therapeutic relevance. U3 Pharma has shown that U3-1900 is an effective inhibitor of tumor cell proliferation in vitro and in vivo.

U3-1800
The target of the U3-1800 antibody is a membrane-bound receptor tyrosine kinase whose function had remained unknown until discovered by U3 Pharma and Prof. Axel Ullrich. The target plays an important role in cell migration and invasion in many common types of cancer. U3 Pharma has shown that U3-1800 is an effective inhibitor of tumor cell invasion and migration in vitro and tumor growth in vivo.

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October 22, 2017 by u3PH.rma

How to know if your beauty products are tested on animals

Today many companies rely on animal testing to ensure their products are safe for humans. Yet, concerns about extreme cruelty are growing and cosmetics companies are making a shift towards cruelty-free products. Yet, how do you know that your best liquid lipstick has not been tested on animals? If you are conscious about what products you buy, maybe you already have an idea about which companies’ products to avoid, but for those of you, who are new to this, the following advice will be of interest.

Be aware that companies use third-party ingredients, which may be animal-tested only by the third party, but not by your company of choice. This is a huge loophole in the system as it brings more controversy to the table.

Another concern is misleading labeling of products. It’s very common that one ingredient of the cosmetics product was tested on animals, but the final combination of all ingredients wasn’t. Companies take advantage of that and label the product “cruelty free” or “not tested on animals”.

Yet a third problem are the seemingly insignificant ingredients, hiding behind names like Keratin, Retinol, Lecithin, Casein, Lactic Acid, etc. All these ingredients are animal by-products like blood, saliva, animal protein, animal fat, etc.

So, you may ask yourself how to be 100% sure that your beauty products are cruelty free. There are five easy ways to spot cosmetics not tested on animals.

First of all, look for the label “Vegan”. Vegan always implies that none of the ingredients in the product were derived from or tested on animals. Another clear-cut sign is the Leaping Bunny logo. The Leaping Bunny project ensures that a list of brands are cruelty-free and only after close inspection, the bunny logo is added to the product’s label.

These are possibly the three easiest steps for you to take. The rest lies in your hands. Many users spend a lot of time researching online databases, resources, articles and lists of cruelty-free companies, which are often updated with the latest news.

Also, be always on the look-out – you never know if your favorite brand has decided to change some ingredients. If the updated formula hasn’t yet been tested for cruelty-free ingredients, you may want to be vigilant.

In addition, you can download cruelty-free apps like “Cruelty Cutter”, “Leaping Bunny App”, “Bunny Free App (PETA)” and “Choose Cruelty Free App”. You can scan the product’s barcode and the app will immediately display the information you need to have. Keep in mind that some apps may show different data, so don’t rely on one app only. Some more reliable apps may cost you $2.99.

Finally, even though it may seem way too simple, we advise that you call the cosmetics company. Showing that you care to use cruelty-free cosmetics will put some pressure on it. The more pressure for products not tested on animals, the higher the chances for change in the industry. There is no guarantee that the company representative will answer in full honesty, yet it is worth the try.

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October 22, 2017 by u3PH.rma

Cosmetics and the Lasting Effect on Your Skin

Cosmetics have become the need of time these days. Rather than being a luxury product, cosmetics are being used daily and essentially by most of us before we go out. A basic reason for this is the fact that with more hectic lifestyles, we are more inclined to resort to quick solutions to fix most of our skin problems such as scars, acne, or pimples and to enhance our features to look good and feel confident.

Makers of these beauty products claim to have conducted a thorough research and testing before introducing any makeup product in the market; but most of the times, these companies compromise on quality to be able to accomplish their profit goals, thus including less-costly harmful chemical ingredients in these products to reduce the overall cost so as to increase their profit margins. Even the most recommended and highly trusted cosmetic brands are never completely harmless and do cause damaging effects on the skin and hair as they are not as completely natural as they claim to be. Say for example, the best eyeliner for waterline might give you a drop-dead gorgeous and dramatic look, but it can also cause irritation and infection in the eye unless it is used properly and then removed completely before sleep.

Implications of Unnecessary Dependency on Cosmetic Products

People strongly believe that unless they do not use cosmetics, they will not look pretty. They are actually addicted to these products such as the best eyeliner for waterline and desperately dependent on them to look attractive. Some people would even miss out on important occasions if their cosmetics are not available with them. However, we must realize the fact that we all have been created beautiful in our authentic and natural form and do not actually need to rely on these products to make ourselves look better, particularly at the cost of harmful and irreversible effects on our skin and body. Moreover, a better alternative to look naturally beautiful would be to go for home remedies, which may require a long-term consistent use, but will yield spectacular permanent solutions to all your skin problems.

Damaged Hair

Thinning and falling of hair along with redness and irritation in scalp and even chronic dandruff are the harmful effects of various hair styling sprays and gels which are commonly used by many individuals. These conditioners, hair colors, and serums might make you feel cool and look eye-catching but can cause severe damage to scalp skin and sometimes permanent discoloration of hair.

Skin Infections

With the use of fairness creams, foundations, sun blocks and sunscreen lotions, skin diseases have become a common problem. Damage to the skin and particularly facial skin has become a serious torture and can hamper the confidence of anyone. And it turns out to be even worse when it becomes a topic of discussion among social gatherings, making the individuals feel extremely embarrassed.

Harmful For Eyes

People, who use mascaras, kohl liners, eye shadows for bringing out their best features to get an iconic look, are unaware of the harmful effects of these products for their eyes. Chemicals present in these cosmetics can result in damaging effects such as thinning and falling of eyelashes, redness and infections in the eye and at times might cause blindness.

Early Aging

Prolonged use of makeup and beauty products can damage your skin causing pigmentation, acne, pimples, wrinkles and other early signs of aging. The producers of these products then offer solutions in the form of anti-aging creams to make more profits. Beware of these repercussions and avoid using these products on a regular basis.

Headaches

Headaches and dizziness is a common condition that comes along with prolonged use of heavy makeup on skin. It is because these products contain certain harmful ingredients leading to a state of unconsciousness.

Therefore, it is advised to both men and women to choose wearing a lighter layer of makeup at occasions or to use only top of the brand products such as the best eyeliner for Waterline, so that they can avoid worse implications of beauty products on skin and overall health.